What is tenosynovial
giant cell tumor (TGCT)?
What is tenosynovial
giant cell tumor (TGCT)?
TGCT is also formerly known as pigmented villonodular synovitis (PVNS) or giant cell tumor of the tendon sheath (GCT-TS)
TGCT is a chronic disease where tumors form in the body's joints causing pain, swelling, and loss of range of motion in the affected joint. TGCT may cause permanent damage to the joint.*
*In a study of patients with diffuse TGCT, 8 out of 45 patients (18%) who did not have osteoarthritis at baseline developed signs of joint damage.
11-50 casesper million people annually
33 years of agethe median age of diagnosis
TGCT is also formerly known as pigmented villonodular synovitis (PVNS) or giant cell tumor of the tendon sheath (GCT-TS)
TGCT is a chronic disease where non-malignant tumors form in the body's joints causing pain, swelling, and loss of range of motion in the affected joint. TGCT may cause permanent damage to the joint.*
*In a study of patients with diffuse TGCT, 8 out of 45 patients (18%) who did not have osteoarthritis at baseline developed signs of joint damage.
There are two types of TGCT:
Localized/nodular TGCT is more common and tends to be smaller, well‑defined tumors inside or outside of the joint.
Diffuse TGCT is less common and tends to be larger tumors with ill‑defined boundaries.
For use in adult patients only.
“Because TGCT is benign, people automatically think it can be fixed. The truth is, it can still be serious and have a major impact on day-to-day life.”
– Debbie,a real patient on ROMVIMZA
High recurrence can potentially create lifelong burdens:
Up to 72% recurrence rate for diffuse TGCT- Up to 15% recurrence rate for localized/nodular TGCT
TGCT can significantly impact daily living
According to an observational study of 497 adults with TGCT, conducted by TGCT Support:
- 92% of patients reported pain, with pain impacting many areas of daily life, from household chores and social activities (77.9%) to family life (75.9%)
- 85% of patients reported limited range of motion
- 23% of patients reported that they changed occupations or retired early due to their TGCT, with higher rates in patients who had more than 2 surgeries
- Impact on household activities, including:
- Daily chores, like vacuuming or yard work (73.9%)
- Going for a walk that lasts at least 15 minutes (63.3%)
- Running errands and shopping (62.0%)
- Going up and down the steps at a normal pace (77.1%)
Treating TGCT: surgery or prescription medicines?
While TGCT is often treated with surgery, surgery isn't right for everyone, and not all tumors can be removed.
Want to learn more about TGCT?
TGCT Support has information, statistics, support, and resources to help you better understand the condition.†
†TGCT Support is an independent organization that is not affiliated with Deciphera. Deciphera is not responsible for the content on TGCT Support’s website or any services or materials it may provide.